Cryptophycin Anticancer Drugs Revisited

Natural Based Anticancer Drugs and Their Worthiness

Chromatography of Anticancer Drugs

Chromatographic techniques have been developed and successfully applied for the analysis of a considerable of number of organic and inorganic compounds present at trace level in sometimes complicated accompanying matrices. The rapid development of new chromatographic instrumentation and separation strategies resulted in the increase of the number of chromatographic technologies with higher sepa...

Mechanisms of anticancer drugs

Introduction 34 Principles of chemotherapy 34 Principles of tumour biology 34 Classification of chemotherapeutic agents 37 Limitations of cytotoxic agents 40 Chemotherapy in head and neck cancer 40 Choice of chemotherapy in head and neck cancer 40 Chemotherapy strategies 40 Novel therapies for the future 41 Other novel treatments 44 Conclusion 44 Key points 45 Deficiencies in current knowledge ...

Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module.

Cryptophycins (Crp) are a group of cyanobacterial depsipeptides with activity against drug-resistant tumors. Although they have been shown to be promising, further efforts are required to return these highly potent compounds to the clinic through a new generation of analogues with improved medicinal properties. Herein, we report a chemosynthetic route relying on the multifunctional enzyme CrpD-...

Nezw Drugs Anticancer chemotherapy

Though the selection and administration of cytotoxic drugs is usually restricted to specialist units, all doctors should be aware of both the available treatment and its associated problems. This review concerns new cytotoxic drugs and some new applications of current drugs. It is largely confined to drugs marketed in the United Kingdom in the past five years and drugs from abroad that are curr...